Physiological learning involves intrasynaptic reorganization of GluA1-containing AMPA receptors
Learning and memory formation depend on persistent modifications of excitatory synaptic transmission in the hippocampus through changes in AMPA receptor (AMPAR) content and properties at potentiated synapses. However, directly demonstrating such changes after physiological, behavior-driven learning in the intact brain has remained technically difficult. Using SDS-digested freeze-fracture replica…
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