Nonsense-mediated decay constrains transposable element-driven evolutionary innovation
Nonsense-mediated decay (NMD) degrades transcripts carrying premature termination codons, but its role in controlling transposable element-derived transcript diversity is unclear. We assembled an NMD-extended transcriptome (~217,000 transcripts, ~80% unannotated) from long-read RNA sequencing of cell lines after NMD inhibition. NMD-regulated transcripts were enriched in TE exonization,…
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