Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses
The requirement for COVID-19 vaccines to be continually updated has highlighted a need for coronavirus vaccines offering broader protective immunity. Adenovirus (Ad) vector vaccines induce potent T-cell responses in humans, but homologous boosting of vaccine-specific antibody responses is often modest compared to other technologies including protein nanoparticles. Here, we designed a…
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