Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation
Metabolite-based polymer nanoparticles can transform endogenous immunometabolites into intrinsically bioactive materials, yet most platforms have focused on itaconate or soluble metabolite analogs. Mesaconate is a downstream itaconate-derived immunometabolite with distinct metabolic activity, but its potential as an engineerable material building block remains largely unexplored. Here, mesaconic…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
