Mycobacterium tuberculosis (Mtb) causes more deaths annually than any other pathogen, yet an effective vaccine remains elusive. IFN-γ-producing Th1 CD4+ T cells are necessary but insufficient for protection against infection. In humans, the development of IL-17A-producing Th17 T cells correlates with protection; however, not all individuals develop a Th17 response. In mice, experimental vaccines…
Consumer sentiment in the U.K. tumbled at the fastest pace since the Covid-19 pandemic this month as mounting cost-of-living pressures reversed the bounce in optimism seen over the summer.
