Expanding Therapeutic Target Space from Genes to Disease-Relevant Molecular Forms with Agent3Diso
Therapeutic targets are commonly defined at the gene or canonical protein level, yet therapeutic effects are ultimately exerted through specific molecular states operating in specific biological contexts. Alternative splicing generates diverse RNA and translated protein forms whose functional consequences, disease relevance, and therapeutic vulnerabilities can differ substantially within the same…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
