Dysregulated mechanoregulation of load-induced bone adaptation in prematurely aged mice: insights from a micro-multiphysics agent-based model
Bone exhibits remarkable ability to adapt to varying mechanical demands. Aging can lead to changes in distribution of cells and proteins that directly affect bone formation and resorption. Given the inherent challenges of quantifying these cellular and protein alterations in vivo, innovative in silico tools have proven useful to contribute to studying the impact of aging on bone mechanobiology…
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