Cellular Traction and Morphological Adaptation to Cell-Scale Stiffness Gradients on Length-Encoded Micropillar Arrays
In tumour microenvironments, cancer cells routinely encounter abrupt and spatially heterogeneous stiffness variations at the scale of individual cells. How cells sense and respond to such steep, local stiffness gradients is not well understood. Here, we developed length-encoded micropillar arrays in which stiffness is set by the effective pillar length, while the pillar tops remain at the same…
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