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Bispecific dual T cell agonist invikafusp alfa in solid tumors: the phase 1/2 START-001 trial

Nature Medicine, Published online: 23 October 2026; doi:10.1038/s41591-026-04711-0 As presented at the European Society for Medical Oncology Congress 2026, in a phase 1/2 trial in participants with solid tumors, invika, a first-in-class bispecific agonistic antibody that selectively targets the prevalent Vβ6/Vβ10 T cell subsets, was well tolerated, enabling the selection of a recommended phase 2…

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