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Small molecules targeting BRCA1-deficient cancer cells

BRCA1 mutation-carriers frequently develop triple-negative breast cancers that are resistant to cancer therapies. We used our established luciferase-expressing BRCA1-deficient human mammary epithelial-derived cell line series with stable shRNA-mediated BRCA1-knockdown, H-RasG12V-mediated transformation, and TP53-deficiency (PMID: 20038817) to perform a high-throughput-screen using the National…

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

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AI Detects Half of Lung Cancers Missed on Neck CT Scans, Highlighting New Opportunities for Medical Imaging

Artificial intelligence could help identify lung cancers overlooked during routine interpretation of CT scans performed for other medical purposes, according to a new study highlighting the potential…

  • AI software AVIEW LCS detects 51.3% of lung cancers missed in neck CT scans
  • Study analyzes 81,794 CT exams, finds 80 cancers not documented initially
  • AI uncovers additional diagnostic information without extra imaging exams

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