Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I
CD8+ T cell recognition of pathogen-derived peptides presented on major histocompatibility complex class I (MHC-I) contributes to protective immunity against intracellular pathogens like Mycobacterium tuberculosis (Mtb). However, it is currently difficult to predict which microbial antigens will be presented on MHC-I by infected cells. Prior studies have shown that proteins exported by Mtb's type…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
