Lab study shows needle-free mRNA vaccine protects against COVID and flu
A needle-free vaccination method protected mice against the viruses that cause COVID-19 and flu, offering a possible new way to deliver mRNA vaccines while limiting unwanted inflammation.
A needle-free mRNA vaccine has shown promise in protecting mice against both COVID-19 and flu viruses, suggesting a potentially new method for delivering these vaccines. The research from Rutgers University and Japanese institutions explored the use of a high-pressure liquid jet to deliver mRNA directly into the skin, bypassing the need for traditional needles.
Two adjuvants, aluminum phosphate and short DNA molecules called CpG, were added to enhance the immune response. When combined, these adjuvants significantly improved both antibody and cellular responses compared to using them individually or without adjuvants. After three doses, the vaccine protected mice against infectious SARS-CoV-2 or influenza A, with viral RNA levels in their lungs reduced by about 24 times compared to unvaccinated mice.
Importantly, this approach resulted in less local and systemic inflammation than traditional lipid-particle formulations of mRNA vaccines. However, further testing in larger animals is needed before human trials can begin, including determining appropriate doses. The researchers are encouraged by these results, noting that both the delivery device and adjuvant components have already been used in human patients, indicating potential for safe clinical application.
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