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Spontaneous brain-wide rotational dynamics constrain cue-evoked behavior

Uncovering low-dimensional representations of brain-wide neural dynamics and their relationship to behavior remains a central challenge. Here, we show that spontaneous brain-wide rotational dynamics constrain cue-evoked behavior and learning. To systematically establish these findings, we developed a dimensionality-reduction technique called Rotational Component Analysis (RCA) that optimizes the…

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