METTL1 gene dosage and catalytic activity define a targetable vulnerability in pediatric cancers
METTL1 is responsible for catalyzing N7-methylguanosine (m7G) methylation of tRNAs. METTL1-dependent oncogenic mechanisms include both its methyltransferase catalytic activity and, in specific instances, non-catalytic interactions that maintain aminoacylated tRNA levels in malignant cells. We show that METTL1 copy number gain and elevated expression are a feature of pediatric tumors that are…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
