IFNα differentially disrupts stimulus-secretion coupling in pancreatic alpha and beta cells
Aims/hypothesis: IFN contributes to early islet inflammation and beta cell immunogenicity in type 1 diabetes, but its direct effects on endocrine cell function remain incompletely understood. We investigated whether acute IFN exposure disrupts glucose-regulated insulin and glucagon secretion and whether the underlying alterations in stimulus-secretion coupling differ between beta and alpha cells.…
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