Activity-gated exocytosis drives myelin remodeling required for adult learning
Myelin remodeling is emerging as a dynamic facet of plasticity in the adult brain. Learning and sensory experience induce remodeling of existing myelin sheaths through incompletely understood mechanisms, leaving its causal contribution to adaptive behaviors unclear. Here, we identify activity-dependent exocytosis in mature oligodendrocytes as a key driver of myelin remodeling. Live-cell imaging…
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