Structural analysis reveals three families of bacterial tRNA mimics
Comparative genomics has identified over 1,000 candidate structured RNA motifs, yet most remain functionally uncharacterized. Here, we combine crystallography, comparative analysis, and bacterial genetics to identify three families of bacterial tRNA-like RNAs. The skipping-rope RNA adopts an L-shaped fold resembling tRNA despite distinct secondary-structure connectivity and tertiary interactions.…
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