NFL Week 6 betting: 5 biggest storylines, including how Rams upset loss shook up the odds

The biggest upset of the NFL season, in terms of point spread, occurred in Week 6 when the Los Angeles Rams lost as a 12.5-point favorite to the Arizona Cardinals. This marked just the third time in NFL history that a favorite of 12.5 points or more has lost, the other instances being the Titans beating the Dolphins (13.5-point favorite) and the Packers losing as 13-point favorites to the Panthers.

The Rams' loss had significant implications for the betting lines, particularly for the upcoming Week 7 game against the Raiders, now listed as a 4.5-point favorite.

Following their loss to the Cardinals, the NFL betting community expressed less confidence in the Rams. Their line moved from Rams -7 to Rams 4.5-point favorite for Week 7, with injuries to key players like receiver Davante Adams and defensive lineman Kobie Turner contributing to the spread movement. Despite a backdoor cover against the Bills on Sunday, the shift in the Rams' line was primarily due to their recent poor performance.

The Rams' fortunes took a turn in the Super Bowl odds market following their Week 6 loss. While they were initially favored or tied for the top spot, they have since dropped to fifth with odds of +1200 at BetMGM. Although it's unusual for a 2-4 team to have such favorable odds, the change underscores the impact of the Rams' Week 6 defeat.

The Los Angeles Chargers remain the only NFL team without a cover on the spread this season, with a record of 0-6. They are scheduled to play against the Rams after their bye week, a matchup that could be crucial for their playoff chances. Meanwhile, the Kansas City Chiefs, who have had a dominant start with a 5-0 record, are not favored against the Seattle Seahawks, who are a -2.5-point underdog. The Chiefs' upcoming matchup against Seattle could provide a significant test for their undefeated season.