Lowly polymorphic pathogen proteins may not be under evolutionary constraint
A central challenge in infectious disease biology is anticipating whether pathogen proteins targeted by vaccines, drugs, or diagnostics can evolve in ways that reduce intervention efficacy. Evolutionary constraint is therefore relevant to selecting targets likely to remain effective after deployment. Yet low diversity in contemporary pathogen populations is often interpreted as evidence of…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
