Functional heterogeneity, tumor vascularization, and the nonlinear dynamics of metastatic cancer treated by oncolytic viral therapy
Oncolytic viral therapy (OVT) is an emerging cancer treatment where therapeutic viruses are injected into a patient. Models have been developed which describe the interactions of the virus, tumor and immune system through systems of nonlinear ordinary differential equations (ODEs). Some suggest that an initial phase of treatment with immunosuppressants could improve the efficacy of OVT by…
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