Estradiol Modulates Cytotoxic Responses to Topoisomerase II Targeting Agents in Estrogen Receptor Positive Breast Cancer Cells
Endocrine therapy is the primary treatment for estrogen receptor-positive (ER+) breast cancer. Paradoxically high dose estradiol can induce ER+ breast cancer cell death in an ER dependent manner. Although a well-established phenomenon, the mechanism of estradiol (E2)-induced breast cancer cell death has remained elusive. More recent evidence has revealed that E2 drives estrogen receptor alpha…
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