Structural basis for aphidicolin inhibition of human processive DNA synthesis
Eukaryotic DNA replication requires RNA--DNA primer synthesis by Pol and processive lagging- and leading-strand synthesis by Pol {delta} and Pol {epsilon} respectively, tethered to the PCNA clamp. Aphidicolin, a fungal diterpenoid, is a selective inhibitor of these B-family polymerases and a tool for inducing controlled replication stress, yet its structural mechanism has been defined only for…
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