Role of the lipolysis stimulated lipoprotein receptor LSR in the regulation of macrophage lipid homeostasis and metabolic activity
In atherosclerosis, monocyte-derived macrophages in the subendothelial space of the arterial wall, become lipid-laden and pro-inflammatory. Macrophages depend on lipoprotein receptors to regulate lipid influx, thereby shaping macrophage metabolic state and potentially dictating their phenotype. The lipolysis stimulated lipoprotein receptor, LSR, contributes to lipid homeostasis and was detected…
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