Loss of the UFM-1 pathway enhances the ER Unfolded Protein Response under stress to improve proteostasis and organismal health in Caenorhabditis elegans
The ubiquitin-like molecule (UBL) Ubiquitin-Fold Modifier 1 (UFM1) has emerged as an important regulator of protein quality control at the endoplasmic reticulum (ER). In humans, dysfunction of the UFM1 pathway is associated with neurodevelopmental diseases and cancer, however the physiological functions of the UFM-1 pathway are not well understood. Here, we used loss-of-function mutants in C.…
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