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Enhancement of gut-microbiome-based classification of prodromal Parkinson's Disease cases by hyperparameter tuning, integration of multimodal data, and meta-analysis.

Parkinson's Disease (PD) is often preceded by a prodromal phase marked by non-motor symptoms such as REM Sleep Behaviour Disorder (RBD), gastrointestinal dysfunction, and olfactory impairment. Mounting evidence implicates gut microbiota in the early pathophysiology of PD. In this study, we aimed to enhance the classification of prodromal PD using gut microbiota profiles, with a focus on model…

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