Elevated cortical tension triggers precocious ectopic polarization in mammalian oocytes, associated with lower developmental potential.
Oocytes from many organisms polarize early during development, unlike mammalian oocytes. The significance of maintaining this homogeneous state in mammals remains unclear. We show that elevated cortical tension, via increased actomyosin contractility or disrupted cortical architecture, induces precocious cortical polarization mid-meiosis I, with an ectopic actomyosin-rich domain opposite the…
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