Dynamin-2 is a fission factor for SNX1-coated endosomal tubules
Sorting nexins of the SNX-BAR family shape endosomal membranes into tubular carriers that route cargo away from the degradative pathway, but we poorly understand the machinery that cuts these tubules to release transport carriers. Here we show that Dynamin-2 (Dyn2) is a fission factor for SNX1-coated tubules. In HeLa cells, Dyn2 localises to SNX1 tubules, and its knockout lengthens them and…
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