DNAJC13 restricts TLR7-driven autoimmunity in mice and humans
Detection of RNA by endosomal Toll-like receptor 7 (TLR7) and TLR8 enables broad microbial sensing while also introducing the risk of autoimmune disease due to responses against self-RNA. Accordingly, the levels of TLR7/8 must be carefully tuned to limit activation by self-ligands that reach the endosomal compartments where these receptors function. Receptor localization and turnover have been…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
