Cross-generational characterization of paternal Low Protein Diet effects in mice
The impact of diet on the physiology of organisms and their progeny has been well documented across phyla. Using the established paternal Low Protein (LP) diet paradigm in mice, here we assess the robustness of the diet-induced intergenerational responses upon variation of genetic background and dietary history of tested animals. Protein restriction in FVB/NCrl resulted in mild, but specific…
The study explores the effects of paternal Low Protein (LP) diet on the physiology of mice, focusing on intergenerational responses and their variation based on genetic background and dietary history. The research demonstrates that a mild, specific hepatic response to protein restriction in FVB/NCrl mice was observed in both exposed animals and their F1 progeny.
These effects impacted fatty acid metabolism and cholesterol biosynthesis. The shared molecular mechanisms responsible for these metabolic reprogramming phenomena were found to be consistent between FVB/NCrl and C56BL/6J mice. However, the study reveals unexpected cumulative intergenerational inheritance effects that change at each generation.
Additionally, a sex-specific priming of cholesterol metabolism in LP-sired F1 offspring was discovered, which becomes evident after dietary challenge. Overall, the findings suggest that phenotypic consequences of paternal LP consumption are influenced by the duration of dietary exposure and its interaction across generations, resulting in distinct trajectories in hepatic energy metabolism.
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