An intrinsically disordered adaptor protein controls the size and composition of EGFR condensates on membranes
Receptor phase separation is common in signaling pathways, yet mechanisms that limit condensate size and drive their dissolution remain poorly understood. For example, phosphorylated EGFR forms large micron-scale condensates in vitro, but assembles into smaller nanoscale clusters in cells, suggesting cellular regulation of condensate size. Here, we show that the intrinsically disordered adaptor…
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