The SARS-CoV-2 spike receptor-binding domain has evolved decreased inherent antigenicity in humans
The SARS-CoV-2 spike protein has evolved rapidly since the virus began circulating in the human population. This evolution has been strongly driven by pressure to escape neutralizing antibodies, which predominantly target the spike's receptor-binding domain (RBD). Many studies have shown that mutations to the RBD during SARS- CoV-2 evolution have abrogated binding by neutralizing antibodies…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
