The nuclear Argonaute HRDE-1 broadly interacts with euchromatin via an RGG domain to enable transgenerational epigenetic silencing
Small RNA(sRNA)-guided transcriptional repression, a process termed as nuclear RNAi, safeguards genome integrity and germline development. Central to this pathway are the highly conserved Argonaute (AGO) proteins, which are guided by sRNAs to mediate transcriptional silencing and heterochromatin formation at the target locus. The mechanism of how nuclear AGO proteins engage chromatin remains…
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