The hepatic sinusoid is a site of microvascular complications of hyperglycemia
Diabetes is the strongest independent predictor of progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to cirrhosis and hepatocellular carcinoma, yet how glucose injures the liver is poorly understood. In the retina and kidney, hyperglycemia damages the microvascular endothelium through a shared mechanism in which unrestricted glucose entry inhibits…
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