Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation
Sleep disturbances are common early features of neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). AD progression is also characterized by early and substantial degeneration of the noradrenergic locus coeruleus (LC), beginning with tau pathology and progressing to major neuronal loss. Although LC degeneration and sleep disruption progress in parallel,…
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