Nucleotide State Regulates Asymmetric Substrate-Binding Protein Docking in a Type II ABC Importer
Type II ABC importers rely on substrate-binding proteins (SBP) to capture nutrients and deliver them to membrane-embedded transporters, but how ATP binding and hydrolysis regulate their interactions remains poorly understood. To address these questions, we determined structures of the Type II small-substrate molybdate importer MolBC-A from H. influenzae in distinct nucleotide-bound states,…
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