Nanopore sequencing reveals the DNA replication timing programme of the malaria parasite Plasmodium falciparum
The DNA replication timing programme, defined as the temporal order in which genomic loci replicate, is of fundamental importance to maintaining genome stability. In human cells, replication timing is routinely measured using Repli-seq which reveals that the human genome is divided into replication timing domains that replicate in early or late S-phase. These timing domains are associated with…
Two identical sisters were born carrying the same rare cancer, an undifferentiated sarcoma driven by a unique gene fusion (MN1::ZNF341). Researchers sequenced the genetic code of healthy and tumor tissues, along with placental samples, to trace the cancer's journey between the twins. The findings, published in Nature Communications, revealed that the cancer likely began as a facial tumor in Twin A at the end of the first trimester, which then crossed the placenta to reach Twin B late in the second trimester.
This study challenges the classical model of identical twin development and highlights the extremely rare occurrence of both twins developing the same cancer, either independently or through placental transmission.
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- DNA sequencing reveals how rare cancer spread between twins before birth medicalxpress.com
