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Kilohertz electrical stimulation drives widespread neuronal activation and temporal interference imposes focal rhythmic modulation

Temporal interference (TI) stimulation has attracted attention as a non-invasive approach that can target deep brain structures through interacting kilohertz-frequency electric fields. Its basic premise is that TI stimulation evokes neuronal responses through low-frequency amplitude modulation (AM), while the underlying kilohertz-frequency stimulation is ineffective to induce activity, the latter…

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