Dynamic regulation of cystathionine gamma-lyase expression during normoxia, ischemia, and reperfusion in liver: interplay of transcription factors, microRNAs, and histone modifications
Cystathionine gamma-lyase (CTH), a key enzyme in hydrogen sulfide (H2S) biosynthesis, has been studied extensively in models of oxidative stress. Dysregulated CTH has been reported in cardiovascular disease, ischemia-reperfusion (I/R) injury, aging, and xenobiotic stress, where reactive oxygen species are central to pathology. Despite this, how CTH is regulated at the molecular level under basal,…
France and Germany have backed looser EU emissions rules for carmakers and agreed to include Britain in a “made in Europe” scheme, in a provisional deal reached Thursday that could reshape the bloc’s…
Researchers at the University of Miami have identified a group of previously unknown viruses that bridge an evolutionary gap between viruses and cellular protein compartments, a discovery with…
Female protagonists in animated films have come a long way over the past several decades. Take the 1959 movie "Sleeping Beauty": Soft-spoken and vulnerable, Princess Aurora is cursed as an infant by…
For adults with type 2 diabetes, longer sleep duration is associated with an increased risk for incidence and progression of diabetic nephropathy, according to a study published online Oct.
