Denoising broadband CARS hyperspectral images on variance-stabilized data: a unified benchmark
Broadband coherent anti-Stokes Raman scattering (BCARS) enables label-free hyperspectral chemical imaging, but weak signal components are often obscured by heteroscedastic noise. Here, we develop a physics-based variance stabilization transform and benchmark six hyperspectral denoising methods to identify effective strategies for BCARS noise reduction. The transform yields nearly…
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