Atypical T cell receptor signalling permits distinct gut gd T cell responses to healthy versus dysregulated tissues
Intraepithelial lymphocytes (IEL) are conserved across vertebrates and commonly enriched in {gamma}{delta} T cells. Several such {gamma}{delta} IELs depend upon homeostatic interactions of their T cell receptors (TCRs) with butyrophilin-like (BTNL) proteins expressed by healthy enterocytes and colonocytes. What limits such interactions from inducing full-blown T cell activation which would…
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