ARID5A Is a PERK-Dependent Effector of the Endoplasmic Reticulum Stress Response That Protects Against Steatohepatitis
Lipotoxic endoplasmic reticulum (ER) stress is a fundamental feature of metabolic dysfunction-associated steatohepatitis (MASH). ER stress activates adaptive signaling processes that aim to restore ER homeostasis. Yet, depending on the duration, magnitude, and cellular context, sustained ER stress becomes maladaptive and leads to cell death. The regulatory pathways that determine adaptive versus…
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