Argonaute loss is associated with reduced endogenous leishbuvirid RNA abundance and disruption of viral small RNA accumulation in Leishmania martiniquensis
Leishmania (Mundinia) martiniquensis is an emerging and under-researched protistan parasite of humans and animals. It contains an endosymbiotic bunyavirus, LmarLBV1 (Leishbuviridae) and the nature and regulation of this interaction are poorly understood. Here we investigated the role of RNA interference (RNAi) in controlling LmarLBV1 replication using Argonaute knock out mutants. Unlike the…
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