A host enzyme pseudouridylates an RNA bacteriophage genome and accelerates virus production
RNA modifications are prevalent and potent regulators of gene expression across all domains of life. However, whether they exist in bacteriophages and whether they impact phage-host interactions are largely unexplored. To address this, we leveraged the ssRNA bacteriophage MS2 and its E. coli host. Using quantitative nanopore direct RNA sequencing and pseudouridine profiling, we found that…
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