Decoupling of spontaneous and evoked activity in locus coeruleus neurons: early synaptic and ion-channel remodeling in a mouse model of Alzheimer's disease
The locus coeruleus (LC) is among the earliest brain regions affected in Alzheimer's disease (AD), yet the mechanisms underlying its early vulnerability remain poorly understood. Clarifying synaptic and intrinsic dysfunction in LC noradrenergic (NE) neurons is essential to determine how noradrenergic circuit failure contributes to prodromal AD. We combined whole-cell patch-clamp recordings with…
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