The Role of Locus Coeruleus and Substantia Nigra/Ventral Tegmental Area activity in Reward and Salience Processing: A High-Resolution fMRI Study
Dopaminergic neurons in the substantia nigra/ventral tegmental area (SN/VTA) are classically associated with reward processing, whereas noradrenergic neurons in the locus coeruleus (LC) have been shown to support salience processing more broadly. However, rewarding stimuli are also inherently salient, and in most paradigms reward and salience are conflated, for example when rewarded targets are…
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