Spontaneous Hemodynamic Oscillations during Sleep Coordinate Directional CSF Flow in the Subarachnoid Space and Ventricles
During sleep, cerebrospinal fluid (CSF) flow is enhanced and thought to facilitate clearance of metabolic waste from the brain. Human imaging has shown that sleep is associated with large waves of bulk CSF flow in the fourth ventricle; however, the CSF flow dynamics around brain tissue are unknown. Here, we investigated how CSF flow is organized across the subarachnoid space, a key site both for…
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