Proteomics of steady-state and culture-derived human erythropoiesis reveals the dynamics of erythroid stress
To generate a mature red blood cell, erythropoiesis requires the committed erythroid progenitor cell and later erythroblast stages to undergo a continuum of extreme morphological and functional remodeling. In vitro culture has been crucial to understand the extensive proteome dynamics that underlie this process. However, the millions of cells required for conventional proteomics technologies…
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