Nicotinic control of dopamine release shapes striatal output and engages adaptive action selection.
Acetylcholine and dopamine significantly modulate striatal circuits and are essential for reward learning and action selection. Cholinergic interneurons can locally trigger dopamine release through beta2-containing nicotinic acetylcholine receptors expressed on dopamine axons1-3. However, the causal contribution of this local cholinergic control of dopamine to behaviour and striatal output…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
