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Human Hippocampal Theta-Gamma Phase-Amplitude Coupling Signals the Distance to Remembered Goals

In mammals, flexible navigation is believed to rely on a cognitive map of known locations supported by the hippocampus and surrounding medial temporal lobe structures. Hippocampal place cells typically exhibit spatial firing fields within a given environment. Moreover, their firing is modulated by the movement-related theta rhythm such that "theta sweeps" of place cell activity encode the…

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