Chromosome 7 gain establishes a just-right WNT signaling state during colorectal tumorigenesis
Aneuploidy is a hallmark of colorectal cancer, yet the functional consequences of recurrent chromosome gains and losses remain largely unknown. Leveraging advances in human colon organoid culture and chromosome copy number engineering, we here identify the gain of chromosome 7 as an adaptive event following APC loss-of-function mutation. Trisomy 7 confers a cell-intrinsic fitness advantage to…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
